K Frank Austen Selected Research

Leukotriene D4

1/2021	The CysLT2R receptor mediates leukotriene C4-driven acute and chronic itch.
5/2016	Leukotriene E4 elicits respiratory epithelial cell mucin release through the G-protein-coupled receptor, GPR99.
4/2013	Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand.
8/2007	Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis.

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K Frank Austen Research Topics

Disease

17	Inflammation (Inflammations) 01/2021 - 06/2002
10	Pneumonia (Pneumonitis) 01/2021 - 03/2004
10	Asthma (Bronchial Asthma) 05/2016 - 09/2003
6	Anaphylaxis (Anaphylactic Shock) 01/2021 - 11/2007
3	Fibrosis (Cirrhosis) 03/2012 - 03/2004
3	Synovitis 11/2007 - 05/2005
3	Arthritis (Polyarthritis) 11/2007 - 05/2005
2	Food Hypersensitivity (Food Allergy) 01/2019 - 10/2015
2	Atopic Dermatitis (Atopic Eczema) 01/2019 - 03/2012
2	Respiratory Hypersensitivity 01/2016 - 04/2006
2	Cicatrix (Scar) 03/2014 - 12/2010
2	Burns 03/2014 - 12/2010
2	Infections 02/2013 - 09/2003
2	Edema (Dropsy) 05/2005 - 08/2003
2	Pulmonary Fibrosis (Fibrosing Alveolitis) 01/2005 - 10/2004
1	Hypersensitivity (Allergy) 01/2021
1	Pain (Aches) 01/2021
1	Mast Cell Activation Syndrome 01/2021
1	Mastocytosis 01/2021
1	Dermatitis 01/2021
1	Neoplasm Metastasis (Metastasis) 01/2019
1	Neoplasms (Cancer) 01/2019
1	Pruritus (Itching) 01/2019
1	Systemic Mastocytosis 01/2017
1	Necrosis 03/2014
1	Sepsis (Septicemia) 10/2011
1	Hyperplasia 09/2009
1	Eosinophilia 09/2009
1	Hypotension (Low Blood Pressure) 12/2008
1	Dyspnea (Shortness of Breath) 12/2008
1	Nausea 12/2008
1	Allergic Rhinitis 02/2008

Drug/Important Bio-Agent (IBA)

13	LeukotrienesIBA 01/2021 - 10/2004
10	Immunoglobulin E (IgE)IBA 01/2019 - 10/2003
8	cysteinyl-leukotrieneIBA 01/2019 - 03/2004
8	CytokinesIBA 01/2017 - 05/2005
6	Leukotriene C4IBA 01/2021 - 10/2004
6	Peptide Hydrolases (Proteases)FDA Link 01/2021 - 06/2005
6	leukotriene D4 receptor (cysteinyl leukotriene receptor)IBA 01/2019 - 03/2004
5	AllergensIBA 10/2019 - 01/2009
4	Leukotriene D4IBA 01/2021 - 08/2007
4	Leukotriene E4IBA 01/2021 - 08/2007
4	AntigensIBA 01/2019 - 10/2004
4	LipidsIBA 05/2016 - 01/2005
3	mouse dectin-2IBA 02/2014 - 01/2009
3	Bleomycin (Blenoxane)FDA LinkGeneric 01/2005 - 03/2004
3	cysteinyl leukotriene receptor 2IBA 01/2005 - 03/2004
2	Biological ProductsIBA 01/2021 - 09/2009
2	IntegrinsIBA 01/2021 - 09/2006
2	Methacholine Chloride (Methacholine)FDA Link 01/2016 - 04/2006
2	Glutathione (Reduced Glutathione)IBA 04/2013 - 11/2004
2	Interleukin-4 (Interleukin 4)IBA 02/2013 - 02/2013
2	Heparin (Liquaemin)FDA LinkGeneric 12/2008 - 06/2008
2	LipopolysaccharidesIBA 11/2007 - 10/2003
2	AutoantibodiesIBA 11/2007 - 04/2006
2	Monoclonal AntibodiesIBA 11/2007 - 05/2005
2	EnzymesIBA 04/2006 - 11/2004
2	Tyrosine (L-Tyrosine)FDA Link 05/2005 - 08/2003
2	ZymosanIBA 10/2004 - 06/2002
2	Blood Proteins (Serum Proteins)IBA 10/2004 - 06/2002
1	RNA (Ribonucleic Acid)IBA 01/2021
1	p-Methoxy-N-methylphenethylamineIBA 01/2021
1	calcipotriene (calcipotriol)FDA LinkGeneric 01/2021
1	Biomarkers (Surrogate Marker)IBA 10/2019
1	Texas redIBA 01/2019
1	AntibodiesIBA 01/2019
1	Dextrans (Dextran)FDA Link 01/2019
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2019
1	Interleukin-13IBA 01/2017
1	Interleukin-5 (Interleukin 5)IBA 01/2017
1	erucylphosphocholineIBA 05/2016
1	Irritants (Vesicants)IBA 01/2016
1	Chemotactic FactorsIBA 01/2016
1	Interleukin-9 (Interleukin 9)IBA 10/2015
1	Fluconazole (Zonal)FDA LinkGeneric 03/2014
1	AcidsIBA 04/2013
1	Interleukin-6 (Interleukin 6)IBA 02/2013
1	LigandsIBA 11/2012
1	Proteins (Proteins, Gene)FDA Link 03/2011
1	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 03/2011
1	Immunoglobulin M (IgM)IBA 12/2010
1	Pancreatic Elastase (Elastase)IBA 12/2010
1	Leukocyte Elastase (Neutrophil Elastase)IBA 12/2010
1	Chymases (Chymase)IBA 12/2010
1	Myosins (Myosin)IBA 12/2010
1	Tryptases (Tryptase)IBA 12/2010
1	CarboxypeptidasesIBA 12/2010
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 06/2010
1	Chemokine ReceptorsIBA 06/2010
1	Arachidonic Acid (Vitamin F)IBA 01/2009
1	C-Type Lectins (C-Type Lectin)IBA 01/2009
1	Chondroitin Sulfates (Chondroitin Sulfate)IBA 06/2008
1	Histamine (Histamine Dihydrochloride)FDA Link 02/2008
1	Immunoglobulins (Immunoglobulin)IBA 11/2007
1	Antigen-Antibody Complex (Immune Complex)IBA 11/2007
1	CollagenIBA 11/2007
1	SRS-AIBA 08/2007
1	Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)IBA 09/2006
1	Leukotriene B4IBA 04/2006

Therapy/Procedure

1	Hematopoietic Stem Cell Transplantation 01/2017